Mice and Hair Loss – What’s the Connection?
According to an article on Discovery News, experiments on mice have linked early hair loss to a gene. According to Japanese researchers, this new find sparks hopes for the treatment and prevention of thinning hair and baldness in humans.
The research found a connection between a gene known as Sox21. This gene is shared by both humans and mice and if it is missing, is linked to thinning hair and baldness.
During the study, the scientists managed to block the gene Sox21 in the rodents. After about 15 days, the rodents started losing hair and within one week, the rodents were completely naked. Normally, when someone loses their hair, new hair grows in its place, but with these mice, they remained bald. Even as the mice grew replacement fur, the hair kept falling out.
The gene Sox21 has been linked to the formation of nerve cells. In the past, this gene has been linked to the formation of nerve cells, but the Japanese study was the first to indicate its function in ensuring hair retention. Some believe that the gene may be the cause of thinning hair in humans. The study was conducted jointly with Hideyuki Okano, professor at the School of Medicine at Tokyo’s Keio University.
The study showed that the lack of the gene leads to the improper formation of the cuticles, which is the outer layer of hair. Cuticles lock the hair into the scalp, normally. When the gene was blocked in the mice, it made their hair fall out more quickly than normal.
Experts are attempting to use the findings of the study to the development of medical treatment against thinning hair. As of right now, experts have no immediate plans for further research to develop the human application.
Many theories regarding hair loss and thinning hair have been disproved. It’s true that hair loss can be a symptom of malnutrition or vitamin deficiency, but this is not always the case. Other theories that have been disproved include:
- You can tell if you’ll lose your hair by looking at your grandfather or father and/or uncles.
- A 40-year-old man who has not lose his hair at this age will never lose his hair.
- Brushing your hair for 100 strokes a day will make your hair healthier and stronger.
According to experts, baldness is primarily the cause of a combination of factors, including aging, hormonal changes and family history. Genetically, there are two different types of hair loss, permanent and temporary.
Other reasons someone may experience hair loss include:
- Physical stress
- Emotional stress
- Thyroid abnormalities and problems
- Medications
- Hormonal changes
Approximately 95 % of permanent hair loss is due to a hereditary condition, affecting millions of men, women and children. This condition is characterized by pattern baldness, which generally starts with a receding hairline.
Most people lose between 50 and 100 strands of hair a day. It can be difficult to estimate how many strands of hair you’re actually losing. If you think you’re losing more hair than you should be, schedule an appointment with your doctor and/or hairdresser.
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Tags: gene Sox21, Hair Loss, hereditary, reasons for hair loss



Hair Loss